Lasix is a potent and fast-acting diuretic derived from sulfonamide. Lasix blocks the Na + K + sulfonate group ion transport system in the thick segment of the ascending knee of the Henle loop. Therefore, its diuretic effect depends on the drug entering the lumen of the renal tubules. The diuretic Lasix effect is associated with inhibition of sodium chloride reabsorption in the section of the Henle loop.
Secondary effects in relation to an increase in sodium excretion are an increase in the amount of urine excreted and an increase in potassium secretion in the distal part of the renal tubule. At the same time, the excretion of calcium and magnesium ions increases. With a decrease in the tubular secretion of furosemide or when the drug is bound to albumin located in the lumen of the tubules, the effect of furosemide decreases. With the course of Lasix, its diuretic activity does not decrease, since the drug interrupts tubular-glomerular feedback in Macula densa. Lasix causes dose-dependent stimulation of the renin-angiotensin-aldosterone system.
Indications for use
- Edematous syndrome in chronic heart failure;
- Edema syndrome in chronic renal failure;
- Acute renal failure, including during pregnancy and burns (to maintain fluid excretion);
- Edematous syndrome with nephrotic syndrome;
- Edema syndrome in liver diseases;
- Arterial hypertension.
During treatment with Lasix, it is necessary to have a constant urine release, as well as to increase the number of products containing potassium in the diet. The use of this drug can also be prescribed for potassium deficiency.
The treatment takes place under careful medical supervision. It is necessary to control the level of sodium and potassium in the blood serum. The drug contains lactose, with which intolerance, it should not be prescribed. When applying Lasix, there is a possibility of exacerbation or activation of systemic lupus erythematosus.
Mode of application
The dosage regimen depends on the degree and place of swelling. In case of a mild swelling syndrome, the recommended initial dose for adults is 20-80 mg when taken orally or 20-40 mg intravenously; in case of severe edema, the dose is increased by 20-40 mg.
In chronic heart failure, the initial dose is 20-50 mg orally per day, divided into 2-3 applications.
In chronic renal failure – 40-80 mg per day.
Edema with liver disease dosage is 20-80 mg per day.
For children, the initial dose is 2 mg/kg body weight or 1 mg/kg with parenteral administration.
The drug is prescribed on an empty stomach.
- Hypersensitivity to the active substance or to any of the components of the drug;
- Patients with an allergy to sulfonamides (sulfonamide antimicrobials or sulfonylureas) may suffer from allergy to furosemide;
- Renal failure with anuria (in the absence of a reaction to furosemide);
- Hepatic coma and precoma;
- Severe hypokalemia;
- severe hyponatremia;
- Hypovolemia (with or without arterial hypotension) or dehydration;
- Pronounced urine outflow violations of any etiology (including unilateral damage to the urinary tract);
- Digital intoxication;
- Acute glomerulonephritis;
- Decompensated aortic and mitral stenosis, hypertrophic obstructive cardiomyopathy;
- Increase in central venous pressure;
- Hyperuricemiachildren’s age up to 3 years (solid dosage form);
Among the side effects, there are:
- dryness and discomfort in the mouth, dry mucous membranes, thirst;
- dyspeptic disorders, nausea, vomiting, abdominal pain, constipation, frequent loose stools;
- pancreatic inflammation;
- hypovolemia, dehydration, a decrease in the level of potassium in the blood, sodium, chlorine, calcium and related disorders, an increase in the concentration of uric acid in the blood;
- inflammation of the skin and its appendages, impaired hearing, vision, crawling, tingling, numbness, dizziness of a systemic and unsystematic nature, muscle weakness;
- urinary retention in patients with a benign tumor of the prostate gland;
- increased cholesterol and “harmful” lipoproteins, as well as triglycerides;
- decreased glucose tolerance based on a laboratory test;
- acute inflammation of the pancreas.
Interaction with other drugs
- When applying Lasix with antihypertensive drugs, a stronger effect of lowering blood pressure is observed.
- With the combined use of Lasix and non-steroidal anti-inflammatory drugs, the diuretic effect can significantly decrease, including acetylsalicylic acid.
- It increases the risk of intoxication with cardiac glycosides, nephrotoxic and ototoxic effects of aminoglycosides and cephalosporins.
When using great doses of the drug, such reactions are possible, mainly due to a large loss of electrolytes and fluid: hypovolemia, dehydration, cardiac arrhythmias, blood concentration, severe arterial hypotension, acute renal failure, confusion, delirium, peripheral paralysis, thrombosis.