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Clomid

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Clomid (clomiphene ) is an anti-estrogenic drug of non-steroidal structure.

Pharmacology

Clomiphene is a gonadotropin production stimulator with antiestrogenic and estrogenic activity. It has a non-steroidal structure, which is close to chlorotrianisene. The effect of clomiphene is due to specific binding to estrogen receptors of the hypothalamus and pituitary gland, which increases the secretion of gonadotropic hormones of the pituitary gland. This, in turn, stimulates the maturation and endocrine activity of the follicle in the ovary, as well as the subsequent formation and stimulation of the function of the corpus luteum. In high doses, the drug inhibits the secretion of gonadotropins. It does not have gestagenic and androgenic activity.

Indications

Clomid is prescribed to patients with:

  • anovulatory infertility (ovulation induction);
  • dysfunctional metrorrhagia;
  • amenorrhea, secondary amenorrhea, post-contraceptive amenorrhea;
  • galactorrhea (against the background of a pituitary tumor);
  • polycystic ovary syndrome (Stein-Leventhal syndrome);
  • Chiari-Frommel syndrome;
  • androgen deficiency;
  • oligospermia;
  • diagnosis of disorders of the pituitary gonadotropic function.

Instructions for use

In the absence of ovulation, a woman receives 50 mg 1 time per day (at bedtime), starting from the 5th day of the menstrual cycle, for 5 days. If the effect does not occur, the dose is increased to 150 mg/day or the course is extended to 10 days. Men with a decrease in sperm count are prescribed 50 mg 1-2 times a day for 3-4 months. The drug is taken regardless of the meal.

Overdose

Symptoms: nausea, vomiting, fever, visual disturbances, ovarian hypertrophy, abdominal pain.

Treatment: symptomatic therapy.

Side effects

Clomid can cause the following side effects:

  • pain in the lower abdomen;
  • visual impairment;
  • dizziness;
  • headache;
  • fatigue;
  • drowsiness;
  • transient visual impairment;
  • nausea;
  • vomiting;
  • diarrhea;
  • allergic skin reactions;
  • weight gain.

Contraindications

Do not take Clomid if you have any of the following conditions/diseases:

  • hypersensitivity;
  • hepatic and / or renal failure;
  • metrorrhagia of unclear etiology;
  • ovarian cyst;
  • malignant and benign neoplasms of the genital organs;
  • swelling or pituitary gland;
  • endometriosis;
  • ovarian failure on the background of hyperprolactinemia;
  • a tendency to thrombosis;
  • bleeding not associated with a violation of ovulation;
  • pregnancy.

Drug interaction

Clomid is compatible with gonadotropin hormones.

Special instructions

Clomifene increases the likelihood of multiple pregnancy.

The drug is effective with a sufficient level of endogenous estrogens, less effective with a low level of estrogen and is practically ineffective with a low concentration of gonadotropic hormones of the pituitary gland. In the course of treatment, constant monitoring by a gynecologist is required.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.